Dr. David Cohen
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Dr. David Cohen
Dr. David Cohen
Internal Medicine - Nephrology & Dialysis
I specialize in
Internal Medicine - Nephrology & Dialysis
I have been in practice
My answers and insights have
Helped 20 people
Here are kind words from others
This Thanksgiving, I wanted to share my appreciation for all that you do! Thank you, doctor! :)
I was educated and trained at
Medical / Graduate School
Jefferson Medical College of Thomas Jefferson University
Heritability of serum sodium concentration: evidence for sex- and ethnic-specific effects.
Physiol. Genomics., Feb;44(3):220-8 (2012)
African American living-kidney donors should be screened for APOL1 risk alleles.
Transplantation., Oct;92(7):722-5 (2011)
The Role of TRPV4 in the Kidney
TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. (2007)
Exploring the potential of mixed-source brachytherapy for the treatment of cervical cancer using high-dose rate 192Ir and/or 50 kV electronic sources.
Brachytherapy., 10(2):141-6 (2011 Mar-Apr)
Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice.
Am. J. Physiol. Gastrointest. Liver Physiol., Sep;299(3):G556-71 (2010)
Absence of AVPR2 copy number variation in eunatremic and dysnatremic subjects in non-Hispanic Caucasian populations.
Physiol. Genomics., Feb;40(3):121-7 (2010)
A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia.
Proc. Natl. Acad. Sci. U.S.A., Aug;106(33):14034-9 (2009)
Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion.
PLoS ONE., 4(5):e5679 (2009)
Effect of VEGF treatment on the blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced magnetic resonance imaging.
J. Neurotrauma., Jul;26(7):1005-16 (2009)
Blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI.
NMR Biomed., Apr;22(3):332-41 (2009)
TRPV4 enhances the cellular uptake of aminoglycoside antibiotics.
J. Cell. Sci., Sep;121(Pt 17):2871-9 (2008)
Real autism plan is needed now.
Mil Med., Jun;173(6):ii-iv (2008)
Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia.
Am. J. Physiol. Gastrointest. Liver Physiol., May;294(5):G1288-98 (2008)
White thrombus formation in blood tubing lines in a chronic hemodialysis unit.
Clin J Am Soc Nephrol., Mar;3(2):382-6 (2008)
Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene.
Am. J. Physiol. Renal Physiol., Dec;293(6):F1865-76 (2007)
The transient receptor potential vanilloid-responsive 1 and 4 cation channels: role in neuronal osmosensing and renal physiology.
Curr. Opin. Nephrol. Hypertens., Sep;16(5):451-8 (2007)
Renal p38 MAP kinase activity in experimental diabetes.
Lab. Invest., Jun;87(6):548-58 (2007)
Regulation of TRP channels by N-linked glycosylation.
Semin. Cell Dev. Biol., Dec;17(6):630-7 (2006)
The role of MAPKs in B cell receptor-induced down-regulation of Egr-1 in immature B lymphoma cells.
J. Biol. Chem., Dec;281(52):39806-18 (2006)
WNK kinases influence TRPV4 channel function and localization.
Am. J. Physiol. Renal Physiol., Jun;290(6):F1305-14 (2006)
Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking.
Am. J. Physiol. Renal Physiol., May;290(5):F1103-9 (2006)
Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant.
Am. J. Physiol. Renal Physiol., Jan;290(1):F117-26 (2006)
Interleukin-10 suppresses tissue factor expression in lipopolysaccharide-stimulated macrophages via inhibition of Egr-1 and a serum response element/MEK-ERK1/2 pathway.
Circ. Res., Aug;97(4):305-13 (2005)
TRPV4 and the mammalian kidney.
Pflugers Arch., Oct;451(1):168-75 (2005)
SRC family kinases in cell volume regulation.
Am. J. Physiol., Cell Physiol., Mar;288(3):C483-93 (2005)
EphA2: expression in the renal medulla and regulation by hypertonicity and urea stress in vitro and in vivo.
Am. J. Physiol. Renal Physiol., Apr;288(4):F855-66 (2005)
Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments.
Am. J. Physiol. Renal Physiol., Jul;287(1):F17-24 (2004)
Estimation of metabolic flux from dominant rate constants in vivo: application to brain and heart.
Metab. Eng., Jan;6(1):59-74 (2004)
Leucine-nitrogen metabolism in the brain of conscious rats: its role as a nitrogen carrier in glutamate synthesis in glial and neuronal metabolic compartments.
J. Neurochem., Feb;88(3):612-22 (2004)
Signaling and gene regulation by urea in cells of the mammalian kidney medulla.
Comp. Biochem. Physiol., Part A Mol. Integr. Physiol., Oct;130(3):429-36 (2001)
Urea and hypertonicity increase expression of heme oxygenase-1 in murine renal medullary cells.
Am. J. Physiol. Renal Physiol., Nov;281(5):F983-91 (2001)
Urea signaling to ERK phosphorylation in renal medullary cells requires extracellular calcium but not calcium entry.
Am. J. Physiol. Renal Physiol., Jan;280(1):F162-71 (2001)
Signalling and gene regulation by urea and NaCl in the renal medulla.
Clin. Exp. Pharmacol. Physiol., Jan;26(1):69-73 (1999)
Hypotonicity activates transcription through ERK-dependent and -independent pathways in renal cells.
Am. J. Physiol., Oct;275(4 Pt 1):C1104-12 (1998)
Urea and NaCl differentially regulate FAK and RAFTK/PYK2 in mIMCD3 renal medullary cells.
Am. J. Physiol., Sep;275(3 Pt 2):F447-51 (1998)
Urea activates ribosomal S6 kinase (RSK) in a MEK-dependent fashion in renal mIMCD3 cells.
Am. J. Physiol., Jan;274(1 Pt 2):F73-8 (1998)
Hypotonicity increases transcription, expression, and action of Egr-1 in murine renal medullary mIMCD3 cells.
Am. J. Physiol., Nov;273(5 Pt 2):F837-42 (1997)
Mitogen-activated protein kinase cascades and the signaling of hyperosmotic stress to immediate early genes.
Comp. Biochem. Physiol. A Physiol., Jul;117(3):291-9 (1997)
NaCl but not urea activates p38 and jun kinase in mIMCD3 murine inner medullary cells.
Am. J. Physiol., Dec;271(6 Pt 2):F1234-8 (1996)
Urea-inducible Egr-1 transcription in renal inner medullary collecting duct (mIMCD3) cells is mediated by extracellular signal-regulated kinase activation.
Proc. Natl. Acad. Sci. U.S.A., Oct;93(20):11242-7 (1996)
Transcriptional responses to tubule challenges.
Kidney Int., Jun;49(6):1678-81 (1996)
Urea inducibility of egr-1 in murine inner medullary collecting duct cells is mediated by the serum response element and adjacent Ets motifs.
J. Biol. Chem., May;271(22):12903-8 (1996)
Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase.
J. Clin. Invest., Apr;97(8):1884-9 (1996)
Hyperosmotic urea increases transcription and synthesis of Egr-1 in murine inner medullary collecting duct (mIMCD3) cells.
J. Biol. Chem., Oct;269(41):25865-70 (1994)
Urea selectively induces DNA synthesis in renal epithelial cells.
Am. J. Physiol., Apr;264(4 Pt 2):F601-7 (1993)
Urea induces Egr-1 and c-fos expression in renal epithelial cells.
Am. J. Physiol., Apr;264(4 Pt 2):F593-600 (1993)
Immediate early gene and HSP70 expression in hyperosmotic stress in MDCK cells.
Am. J. Physiol., Oct;261(4 Pt 1):C594-601 (1991)
CI-926 (3-[4-[4-(3-methylphenyl)-1-piperazinyl]butyl]-2,4-imidazolinedione): antihypertensive profile and pharmacology.
J. Pharmacol. Exp. Ther., Aug;238(2):473-9 (1986)
Antihypertensive profile of the angiotensin-converting enzyme inhibitors CI-906 and CI-907.
Fed. Proc., Apr;43(5):1330-2 (1984)
CI-906 and CI-907: new orally active nonsulfhydryl angiotensin-converting enzyme inhibitors.
Fed. Proc., Apr;43(5):1326-9 (1984)
Antihypertensive effects of CI-907 (indolapril): a novel nonsulfhydryl angiotensin converting enzyme inhibitor.
J. Pharmacol. Exp. Ther., Feb;228(2):312-8 (1984)
Potassium-induced vascular relaxation in two kidney-one clip, renal hypertensive rats.
Pflugers Arch., Jan;396(1):72-8 (1983)
Nitroprusside-induced vascular relaxation in DOCA hypertensive rats.
Hypertension., 4(1):13-9 (1982 Jan-Feb)
Dr. David Cohen M