Dr. Leif Nelin
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Dr. Leif Nelin
Dr. Leif Nelin
Pediatrics - Neonatology
I specialize in
Pediatrics - Neonatology
I have been in practice
My answers and insights have
Helped 20 people
Here are kind words from others
This Thanksgiving, I wanted to share my appreciation for all that you do! Thank you, doctor! :)
I was educated and trained at
Medical / Graduate School
University of South Florida College of Medicine
Dr. Leif Nelin M
I've won the following awards
Listed, Best Doctors in America
Mid-term differences in right ventricular function in patients with congenital diaphragmatic hernia compared with controls.
World J Pediatr., Nov;8(4):350-4 (2012)
Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine.
Am. J. Physiol. Heart Circ. Physiol., Oct (2012)
Factors associated with maternal visitation and participation in skin-to-skin care in an all referral level IIIc NICU.
Acta Paediatr., Oct (2012)
Pharmacologic agents elevating cAMP prevent arginase II expression and proliferation of pulmonary artery smooth muscle cells.
Am. J. Respir. Cell Mol. Biol., Aug;47(2):218-26 (2012)
Lipopolysaccharide-induced cyclooxygenase-2 expression in mouse transformed Clara cells.
Cell. Physiol. Biochem., 29(1-2):213-22 (2012)
Hospital variation in nitric oxide use for premature infants.
Pediatrics., Apr;129(4):e945-51 (2012)
Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps.
J. Immunol., Mar;188(5):2316-27 (2012)
Cancer in pregnancy: fetal and neonatal outcomes.
Clin Obstet Gynecol., Dec;54(4):574-90 (2011)
Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells.
Clin. Exp. Pharmacol. Physiol., Dec;38(12):796-803 (2011)
Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.
Am. J. Physiol. Lung Cell Mol. Physiol., Apr;300(4):L596-604 (2011)
Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine.
Eur. J. Pediatr., Jul;170(7):859-63 (2011)
Inhaled nitric oxide prevents 3-nitrotyrosine formation in the lungs of neonatal mice exposed to >95% oxygen.
Lung., Jun;188(3):217-27 (2010)
Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.
Am. J. Physiol. Heart Circ. Physiol., May;298(5):H1518-28 (2010)
Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.
Am. J. Physiol. Lung Cell Mol. Physiol., Apr;298(4):L600-6 (2010)
Triptolide induces anti-inflammatory cellular responses.
Am J Transl Res., 1(3):267-82 (2009)
Inhaled nitric oxide decreases leukocyte trafficking in the neonatal mouse lung during exposure to >95% oxygen.
Pediatr. Res., Mar;67(3):244-9 (2010)
Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.
J. Immunol., Dec;183(11):7411-9 (2009)
Implementation of a multidisciplinary guideline-driven approach to the care of the extremely premature infant improved hospital outcomes.
Acta Paediatr., Feb;99(2):188-93 (2010)
Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase.
Am. J. Physiol. Lung Cell Mol. Physiol., Dec;297(6):L1151-9 (2009)
Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1.
J. Biol. Chem., Oct;284(40):27123-34 (2009)
Tissue Doppler changes in three neonates with congenital diaphragmatic hernia.
ASAIO J., 55(4):417-9 (2009 Jul-Aug)
Alterations of the thioredoxin system by hyperoxia: implications for alveolar development.
Am. J. Respir. Cell Mol. Biol., Nov;41(5):612-9 (2009)
The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia.
Life Sci., Nov;83(19-20):671-80 (2008)
Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen.
Pediatr. Res., Jan;65(1):33-8 (2009)
Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.
Am. J. Physiol. Lung Cell Mol. Physiol., Oct;295(4):L688-97 (2008)
Endothelin type A receptor antagonist normalizes blood pressure in rats exposed to eucapnic intermittent hypoxia.
Am. J. Physiol. Heart Circ. Physiol., Jul;295(1):H434-40 (2008)
Spatiotemporal characteristics of acid refluxate and relationship to symptoms in premature and term infants with chronic lung disease.
Am. J. Gastroenterol., Mar;103(3):720-8 (2008)
Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.
Am. J. Physiol. Heart Circ. Physiol., Apr;294(4):H1621-9 (2008)
Maturational changes in the regulation of pulmonary vascular tone by nitric oxide in neonatal rats.
Am. J. Physiol. Lung Cell Mol. Physiol., Nov;293(5):L1261-70 (2007)
Increased incidence of idiopathic persistent pulmonary hypertension in Down syndrome neonates.
Pediatr Cardiol., 28(4):250-4 (2007 Jul-Aug)
MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.
Am. J. Physiol., Cell Physiol., Aug;293(2):C632-40 (2007)
Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria.
J. Immunol., Apr;178(8):5312-20 (2007)
MAPK phosphatases--regulating the immune response.
Nat. Rev. Immunol., Mar;7(3):202-12 (2007)
Assessing heparin dosing in neonates on venoarterial extracorporeal membrane oxygenation.
ASAIO J., 53(1):111-4 (2007 Jan-Feb)
Hyperoxia increases hepatic arginase expression and ornithine production in mice.
Toxicol. Appl. Pharmacol., Aug;215(1):109-17 (2006)
Mean airway pressure and response to inhaled nitric oxide in neonatal and pediatric patients.
Lung., 183(6):441-53 (2005 Nov-Dec)
Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide.
J. Mol. Med., May;84(5):405-15 (2006)
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock.
J. Exp. Med., Jan;203(1):131-40 (2006)
Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells.
Am. J. Physiol. Lung Cell Mol. Physiol., Feb;290(2):L298-306 (2006)
Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.
Am. J. Respir. Cell Mol. Biol., Oct;33(4):394-401 (2005)
The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.
J. Biol. Chem., Mar;280(9):8101-8 (2005)
Intratracheal adenoviral-mediated delivery of iNOS decreases pulmonary vasoconstrictor responses in rats.
J. Appl. Physiol., Nov;97(5):1814-22 (2004)
L-lysine decreases nitric oxide production and increases vascular resistance in lungs isolated from lipopolysaccharide-treated neonatal pigs.
Pediatr. Res., Jun;55(6):979-87 (2004)
Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells.
Am. J. Physiol. Lung Cell Mol. Physiol., Jul;287(1):L60-8 (2004)
The use of inhaled nitric oxide in a wide variety of clinical problems.
Pediatr. Clin. North Am., Jun;45(3):531-48 (1998)
Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs.
Am. J. Physiol., Apr;274(4 Pt 1):L517-26 (1998)
Inhaled nitric oxide reduces the utilization of extracorporeal membrane oxygenation in persistent pulmonary hypertension of the newborn.
Crit. Care Med., Feb;25(2):352-9 (1997)
Effect of hypoxia on nitric oxide production in neonatal pig lung.
Am. J. Physiol., Jul;271(1 Pt 2):H8-14 (1996)
Two cases suggesting a role for the L-arginine nitric oxide pathway in neonatal blood pressure regulation.
Acta Paediatr., Apr;84(4):460-2 (1995)
Identification of sepsis in neonates following maternal antibiotic therapy.
Clin Pediatr (Phila)., Mar;34(3):133-7 (1995)
The vascular site of action of hypoxia in the neonatal pig lung.
Pediatr. Res., Jan;35(1):25-9 (1994)
The effect of inhaled nitric oxide on the pulmonary circulation of the neonatal pig.
Pediatr. Res., Jan;35(1):20-4 (1994)
The effect of N omega-nitro-L-arginine methylester on hypoxic vasoconstriction in the neonatal pig lung.
Pediatr. Res., Sep;34(3):349-53 (1993)
A distensible vessel model applied to hypoxic pulmonary vasoconstriction in the neonatal pig.
J. Appl. Physiol., May;74(5):2049-56 (1993)
The effect of blood flow and left atrial pressure on the DLCO in lambs and sheep.
Respir Physiol., Jun;88(3):333-42 (1992)