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Doctor insights on: Thrombolytic Therapy Reperfusion Injury Related

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Are thrombolytic therapy and reperfusion injury related, and how?

Are thrombolytic therapy and reperfusion injury related, and how?

Sort of: Thrombolytic therapy entails breaking off a blocked vessel due to a clot. In the process reperfusion injury can occur to surrounding tissues due to transient lack of oxygen and inflammatory reactions. ...Read more

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Dr. Brad Goldenberg
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Injuries (Definition)

An injury, of any severity, is a condition in which a person has damage to any part of his body. Examples of major injuries include gunshot wounds, knife wounds, large burns, severed ...Read more


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Can antithrombotic and hypofibrinogenetic therapy be used for acute ischemic stroke?

Can antithrombotic and hypofibrinogenetic therapy be used for acute ischemic stroke?

Yes: If ct of brain reveal no bleeding and if the pt. Is in the window period ( less than 4.5 hours from symptoms )to receive fibrinolytics ( tpa (alteplase) or others) this is going to break the clot and restore the circulation avoiding serious neurological damage.Aspirin is started 24. Hrs later after tombolytics. For DVT prevent. Anticoagulants should be used except when hemorrhagic transformation is present. ...Read more

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Is reperfusion injury?

Is reperfusion injury?

Reperfusion injury: Reperfusion injury refers to tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. The absence of oxygen and nutrients from blood during the ischemic period creates a condition in which the restoration of circulation results in leaking from blood vessel the substances that produce damage to tissue - the degraded enzymes create further damage. ...Read more

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Regarding traumatic brain injury.Does recovery occurs at primary injury or secondary injury?

Regarding traumatic brain injury.Does recovery occurs at primary injury or secondary injury?

Please clarify: I am not understanding the question on traumatic brain injury and how recovery takes place...Or when? Would like to help you understand this entity a bit better. ...Read more

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Risk for fetal injury related to reduced placental perfusion from vasospasm?

Risk for fetal injury related to reduced placental perfusion from vasospasm?

Could be: Anytime there is decreased blood flow to the placenta, the fetus will be under some stress, depending on the amount of decreased oxegen and nutrient delivery. ...Read more

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Can chemo therapy causing stroke symptoms?

Can chemo therapy causing stroke symptoms?

Yes: Many types of chemotherapy can directly affect the brain and cause stroke-like symptoms. Some chemotherapy also increases the risk of blood clots, or the risk of bleeding, both of which may cause strokes. Be sure to tell your doctor immediately about these symptoms. ...Read more

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Why thrombolytic therapy is contraindicated in aortic dissection?

Why thrombolytic therapy is contraindicated in aortic dissection?

Bleeding risk: Because doctors tries to balance the possible benefits to the risk of harm. And here with aortic dissection, there is an increased risk of bleeding that exceed the desired benefit, which makes thrombolytic contraindicated in those patients. ...Read more

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Is hyperbaric oxygen therapy an effective treatment for chronic brain injury?

Is hyperbaric oxygen therapy an effective treatment for chronic brain injury?

Research underway: Here are a constelation of studies: http://www.Medicalgasresearch.Com/content/1/1/21. Most studies have been done with severe traumatic brain injury patients. I believe that the jury is still out. ...Read more

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Can hyperbaric oxygen therapy improve recovery from a stroke?

Can hyperbaric oxygen therapy improve recovery from a stroke?

There's no conclusive evidence that hyperbaric oxygen therapy — which involves breathing pure oxygen in a special pressurized chamber — improves the outcome of stroke: Some researchers theorize that increasing the supply of oxygen to the parts of the brain affected by stroke may reduce the extent of irreversible damage. But this has not been proved. Too few people have been studied to say whether hyperbaric oxygen therapy decreases the chance of dying or if it offers other benefits, such as improving the ability to perform everyday tasks. Although hyperbaric oxygen therapy has been found useful in the treatment of a number of conditions — such as decompression sickness and carbon monoxide poisoning — more research is needed to evaluate what, if any, role it plays in stroke treatment. ...Read more

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Does repeat dengue fever (hemorrhagic) cause vascular damage leading to initiating aortic dissection ?

Does repeat dengue fever (hemorrhagic) cause vascular damage leading to initiating aortic dissection ?

No: There is no association between dengue fever and vascular damage. While uncomfortable, df is generally not fatal and recovery is complete. There is no association with aortic aneurysm or dissection. ...Read more

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Is dementia post stroke due to damage from the stoke or later vascular events/?

Is dementia post stroke due to damage from the stoke or later vascular events/?

A progressive: Vascular dementia is based on ongoing damage to the brain which may not be as dramatic as a stroke. Likely there has been some asymptomatc damage even before the stroke. ...Read more

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What therapy is used in patients with acute ischemic stroke?

Time critical: Within 3 hours of symptoms ( up to 4.4 hours in some cases ) intravenous tpa (alteplase). After that up to 6 hours, intraarterial tpa (alteplase) through a catheter in the artery to the brain. Up to 8 hours can use special devices to pull clot out of vessel to brain. These procedures usually done at stroke centers. ...Read more

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Cardiac arrest related to brain inflammation?

Cardiac arrest related to brain inflammation?

Cause of death: Brain swelling (edema) will eventually cause the brain to herniate through one of the layers of protective scaffolding. This usually leads to wild fluctuations in blood pressure and rapidly to respiratory and cardiac arrest. However, the cause of death is the cause of the brian edema, not the cardiac arrest. ...Read more

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Can an acute cerebral vascular accident occur from a recent carotid bruit?

Yes: The bruit may represent carotid stenosis, plaque blocking the artery. If a piece of plaque or clot breaks off, then it can travel to brain causing cva/stroke. Doppler should reveal nature of bruit. Vascular surgeon may be consulted to do endarterectomy or stent, if merited. ...Read more

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Chronic whiplash injury and luq has malfunctioned. Brachial plexus triggers nerve symptoms but nerves not injured. Starting rehab. Healing possible?

Chronic whiplash injury and luq has malfunctioned.  Brachial plexus triggers nerve  symptoms but nerves not injured. Starting rehab. Healing possible?

Get diagnosis first: Be efficient, and get answers as to why your injury did not fully heal. Not uncommon is an injury to the brachial plexus from shoulder strap, with eventual scarring, called thoracic outlet syndrome. Therapy does help, but is a specific approach, such as felderkreis work. Both EMG and ultrasound studies could pin down precise mechanism. If you have tos, about 85% success with conservative rx. ...Read more

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Can radiation therapy lead to carotid artery blockage?

Can radiation therapy lead to carotid artery blockage?

I do not agree: Radiation to the head and neck area could potentially increase the risk for carotid artery disease years after the treatment. I routinely discuss this risk with my patients whom are being treated for a head and neck cancer. Unfortunately, the treatment with radiation is necessary for their disease so the risk of treatment is outweighed by the benfits. ...Read more

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Does hyperbaric oxygen help brain injury or stroke?

Does hyperbaric oxygen help brain injury or stroke?

Yes: We have used hbot for brain injuries of all types for over 10 years and have gotten excellent results. If i ever have a condition of this kind, an hbot chamber is one of the first places i want to be. Jain's textbook of hyperbaric medicine is a good starting place for info about the effects of hbot. ...Read more

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Dr. Brian Santin
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Clot Buster (Definition)

Clot busters are a kind of ...Read more